Microbiota Modulation Induces Elevated Duodenal Eosinophils Upon Gluten Exposure in Mice: Implications for Non-Coeliac Gluten Sensitivity
Jennifer C. Pryor, Emily C. Hoedt, Wai Sinn Soh, Sophie Fowler, Shandelle Caban, Kyra Minahan, Simonne K. Sherwin, Cheenie Nieva, Huw McCarthy, Jay Christopher Horvat, Kateleen E Hedley, Kerith Duncanson, Nicholas J. Talley, Grace L. Burns, Simon Keely
This study shows that antibiotic-induced microbiome modulation in mice alters immune responses to gluten, increasing duodenal eosinophils and activating epithelial γδ T-cells.
bioRxiv · Apr 22, 2025 · PreprintImmunology