Lars G. Engstrand

Multi-omics uncover interactions in the vaginal microbiome and a type II secretion/Tad pilus system in Gardnerella species

This study uses multi-omics to uncover Gardnerella genomic features linked to biofilm formation and interspecies interactions in the vaginal microbiome, identifying potential therapeutic targets for bacterial vaginosis.

Klebsiella pneumoniae T6SS exacerbates gut inflammation promoting tumorigenesis.

This study identifies Klebsiella pneumoniae T6SS as a driver of intestinal inflammation and colorectal tumorigenesis through LPS secretion and immune dysregulation.

Enhanced Computational and Experimental Approaches for Comparative Analysis of the Human Mycobiome

The paper develops and evaluates optimized computational and experimental methods for analyzing the human mycobiome, identifying novel fungal species in oral and gut samples.

Profiling the intestinal microbiota, plasma bile acids and inflammation markers reveals novel associations in Crohn's disease and Ulcerative colitis.

The paper identifies microbiota, bile acid, and inflammation marker associations in Crohn's disease and Ulcerative Colitis using integrated omics data from 1,257 individuals.

RNA degradation analysis reveals ribosome dynamics in complex microbiome samples

The paper analyzes RNA degradation in microbiome samples to study ribosome dynamics and species-specific responses to stress and drugs.

Multiomics and digital monitoring during lifestyle changes reveal independent dimensions of human biology and health

The paper integrates multiomics and digital health data from 96 individuals over 16 months to identify independent molecular factors linked to health outcomes and lifestyle changes.

A comparison of approaches to scaffolding multiple regions along the 16S rRNA gene for improved resolution

This paper compares methods for scaffolding multiple regions of the 16S rRNA gene to improve taxonomic resolution, finding that Sidle provides the least bias and most precise species-level resolution.

Compositional and functional differences of the mucosal microbiota along the intestine of healthy individuals

This study compares mucosal microbiota composition and function along the intestine using shotgun metagenomics, highlighting functional enrichments and antimicrobial resistance patterns.

Optimal protocols for sequence-based characterization of the human vaginal microbiome

This paper evaluates best practices for sequencing-based characterization of the human vaginal microbiome, comparing 16S rRNA gene sequencing and shotgun metagenomic approaches.

A comprehensive automated pipeline for human microbiome sampling, 16S rRNA gene sequencing and bioinformatics processing

The paper develops an automated pipeline for human microbiome sampling, 16S rRNA sequencing, and bioinformatics processing, providing guidelines for sample collection, storage, DNA extraction, PCR, and analysis.