Author

Douglas H. Smith

University of PennsylvaniaORCID 0000-0002-0813-421XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:cell type annotation· 2 Approach:benchmark study· 1 Research Focus:benchmarking· 1 Approach:deep learning· 1 Research Focus:differential expression· 1 Assay:electronic health records· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

John A. WolfiD· 4 shared D. Kacy CulleniD· 3 shared Victoria E. JohnsoniD· 3 shared Alexandra V. UlyanovaiD· 2 shared Kevin D. BrowneiD· 2 shared Rebecca DonahueiD· 2 shared Adel E HelmyiD· 1 shared Bridgette D. SempleiD· 1 shared

Activity by Year

2018-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 22 mutual co-author links

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4 shared papersNeuroscience

John A. WolfORCID

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Author profile →

5 papers

Recent·Most cited

PIGMENT: A deep learning framework for Porcine Immunohistochemistry seGMENTation

Pushkar Ambastha, Javid Dadashkarimi, Sai Krishna C Annavazala, Drew Parker, Ramon Diaz-Arrastia, Hailong Song, Rebecca Donahue, Douglas H. Smith, Jean-Pierre Dollé, Victoria E. Johnson, John A. Wolf, Ragini Verma

PIGMENT is a deep learning framework that automates the segmentation and quantification of APP-positive pathology in porcine white matter histology, achieving high detection rates with limited expert annotations.

bioRxiv · Jun 29, 2026 · PreprintNeuroscience

Increased CD3 Immunoreactive Cells Persist Chronically in the Brain Parenchyma in Association with Focal Cortical Contusion following Experimental TBI

Kristen D Esannason Munroe, Alexandra V. Ulyanova, Rebecca Donahue, John D. Arena, D. Kacy Cullen, Douglas H. Smith, William Stewart, Victoria E. Johnson, John A. Wolf

This study shows that T-cell infiltration persists chronically in the brain after focal cortical contusion in swine, but not with inertial injury, suggesting an adaptive immune response to TBI.

bioRxiv · Feb 15, 2026 · PreprintNeuroscience

Translating from mice to humans: using preclinical blood-based biomarkers for the prognosis and treatment of traumatic brain injury

Ilaria Lisi, Federico Moro, Edoardo Mazzone, Niklas Marklund, Francesca Pischiutta, Firas H. Kobeissy, Xiang Mao, Frances Corrigan, Adel E Helmy, Fatima Ali Nasrallah, Valentina Di Pietro, Laura Benjamin Ngwenya, Luis Valmor Portela, Bridgette D. Semple, Douglas H. Smith, , the InTBIR Fundamental & Translational Working Group

This study reviews preclinical blood biomarkers for traumatic brain injury, finding that NfL and GFAP show promise for prognosis and pharmacodynamic studies.

bioRxiv · Dec 1, 2023 · PreprintNeuroscience

A Porcine Model of Peripheral Nerve Injury Enabling Ultra-Long Regenerative Distances: Surgical Approach, Recovery Kinetics, and Clinical Relevance

Justin C. Burrell, Kevin D. Browne, John L Dutton, Franco A. Laimo, Suradip Das, Daniel P. Brown, Sanford E. Roberts, Dmitriy Petrov, Zarina Sultana Ali, Harry C. Ledebur, Joseph M. Rosen, Hilton M. Kaplan, John A. Wolf, Douglas H. Smith, H Isaac Chen, D. Kacy Cullen

This paper describes a porcine model for studying long-distance peripheral nerve regeneration, focusing on surgical techniques and outcomes for ultra-long regenerative distances.

Neurosurgery · Mar 10, 2020Peer-reviewedNeuroscience

Electrophysiological Signature Reveals Laminar Structure of the Porcine Hippocampus

Alexandra V. Ulyanova, Paul F. Koch, Carlo Cottone, Michael R. Grovola, Christopher D. Adam, Kevin D. Browne, Maura T. Weber, Robin J. Russo, Kimberly G. Gagnon, Douglas H. Smith, Han-Chiao Isaac Chen, Victoria E. Johnson, D. Kacy Cullen, John A. Wolf

The paper characterizes the laminar structure of the porcine hippocampus using histology and electrophysiology, finding features similar to both rodents and primates.

eNeuro · Sep 1, 2018Peer-reviewedNeuroscience