Kenia de los Santos

Engineered probiotics for tumor-targeted combination chemoimmunotherapy

This paper develops a bacterial platform that combines enzyme/prodrug chemotherapy and immunotherapy to enhance antitumor responses with improved safety in a murine tumor model.

Tumor-specific antibodies elicited by engineered bacteria promote bladder cancer immunotherapy

This study shows engineered E. coli expressing CXCL13 enhances bladder cancer immunotherapy when combined with PD-1 blockade by promoting tumor-specific antibody responses.

An amphiregulin reporter mouse enables transcriptional and clonal expansion analysis of reparative lung Treg cells

The paper develops an Areg reporter mouse to study Treg cell transcriptional and clonal expansion in lung repair, identifying 4-1BB agonism as a novel reparative mechanism.

Heparan sulfate regulates amphiregulin signaling towards reparative lung mesenchymal cells during influenza A infection

This study shows heparan sulfate is essential for Areg signaling in lung mesenchymal cells during influenza A infection, affecting reparative responses.