Anjali Saqi

This study uses spatial transcriptomics and lineage tracing to show how tumor subclones drive microenvironmental changes that promote metastasis in a mouse model.

This study shows human terminal airway epithelial cells regenerate alveolar type 1 cells without a type 2 intermediate, co-opting the mouse regenerative mechanism.

This paper develops a human immune system mouse model to study SARS-CoV-2 dissemination and immune responses, finding that human T cells suppress innate immunity and allow viral persistence.

This study identifies that 3q-gain aneuploidy in squamous cell carcinomas creates a vulnerability to SREBP-pathway inhibition, offering a target for lipid-targeted therapies.

This study shows heparan sulfate is essential for Areg signaling in lung mesenchymal cells during influenza A infection, affecting reparative responses.