Sebastián Bernales

Necroptosis inhibition counteracts neurodegeneration, memory decline and key hallmarks of aging, promoting brain rejuvenation.

This study shows that inhibiting necroptosis in aged mice reduces axonal degeneration, neuroinflammation, and memory decline, promoting brain rejuvenation.

Correction of eIF2-dependent defects in brain protein synthesis, synaptic plasticity, and memory in mouse models of Alzheimer's disease

This study shows that reducing eIF2-P in Alzheimer's mouse models improves protein synthesis, synaptic plasticity, and memory.

Small molecule cognitive enhancer reverses age-related memory decline in mice.

Inhibition of the integrated stress response restores neuronal and immune dysfunction and alleviates memory deficits in aged mice.