Sebastian A. Bruijns

Age-related changes in behavioural and neural variability in a decision-making task

This study examines age-related changes in neural and behavioural variability during a decision-making task in mice, finding increased neural variability and reduced variability quenching in specific brain regions.

Brain-wide representations of prior information in mouse decision-making

Mice infer stimulus-side priors from recent choices; prior signals are decodable pre-stimulus in 24.0% to 30.2% of 242 brain regions, including early visual and motor areas.

A Brain-Wide Map of Neural Activity during Complex Behaviour

The paper presents a brain-wide neural activity map from 621,733 neurons across 139 mice performing a decision-making task, showing how neural activity encodes task variables across brain regions.

Low dimensional latent structure underlying the choices of mice

The paper applies a hybrid model to mouse decision-making data to uncover cognitive processes by combining theory-driven and data-driven approaches.

Reproducibility of in-vivo electrophysiological measurements in mice

This study evaluates the reproducibility of electrophysiological measurements across ten labs using standardized protocols and finds that variability in electrode targeting and statistical methods affects reproducibility.

Lightning Pose: improved animal pose estimation via semi-supervised learning, Bayesian ensembling, and cloud-native open-source tools

Data architecture for a large-scale neuroscience collaboration

The paper describes a modular data architecture for a neuroscience collaboration, enabling data contribution, access, and analysis across multiple labs.