Dominik Cysewski

This study identifies RBMXL3 as a primate-specific RNA-binding protein that regulates RNA metabolism and suppresses LINE-1 retrotransposition in human spermatogenesis.

This study identifies RNA length as a species-specific threshold for innate immune recognition, showing that different RNA sensors (RIG-I and MDA5) determine antiviral sensing across human, duck, and chicken cells.

The paper investigates DDX53's role in human germ cells using TCam-2 cells, showing its involvement in RNA metabolism, splicing, and potential interactions with RNA molecules.

The paper shows that effective dsRNA recognition can occur without inflammation, with distinct pathways activated by different RNA features.

This study shows that deleting miR-34a in endothelial cells protects against aneurysm despite causing endothelial dysfunction.

This study shows DIS3L is essential for mouse embryo development but not cell viability, as its absence causes severe embryo degeneration and impaired protein synthesis without affecting cell survival or transcriptome levels.

The paper identifies AMPylated mitochondrial proteins in yeast, revealing a role for AMPylation in regulating ATP synthase activity and OXPHOS coupling.

The paper shows that TENT5C and LARP4/5 work together to maintain globin mRNA poly(A) tails during erythropoiesis, ensuring proper hemoglobin production.

The paper investigates how the CHN-1/UFD-2 complex enhances ubiquitin chain formation through dimerization and chaperone-mediated regulation of substrate ubiquitylation.

The paper shows that mitochondrial proteins are locally synthesized at synapses and incorporated into respiratory chain complexes, supporting local mitochondrial biogenesis.

This study identifies TENT5A as a cytoplasmic poly(A) polymerase essential for collagen production and bone formation, revealing its role in osteogenesis imperfecta type XVIII.

The paper develops a versatile vector system for protein functional analysis and stable cell line generation using FLP-mediated recombination, validated with multiple protein tags and applications.