Qinkun Zhang

Modeling and Correction of Protein Conformational Disease in iPSC-derived Neurons through Personalized Base Editing

This study corrects a pathogenic SERPINI1 mutation in iPSC-derived neurons using a personalized base editor to treat FENIB and related neurodegenerative diseases.

Cardiac fibroblast GSK-3α mediates adverse myocardial fibrosis via IL-11 and ERK pathway

This study identifies GSK-3α in cardiac fibroblasts as a mediator of myocardial fibrosis through the IL-11 and ERK pathway, showing its role in fibroblast activation and cardiac function improvement upon deletion.

CADHERIN-11 BLOCKADE REDUCES INFLAMMATION DRIVEN FIBROTIC REMODELING AND IMPROVES OUTCOMES AFTER MYOCARDIAL INFARCTION

This study shows that blocking CDH11 reduces inflammation-driven fibrosis and improves cardiac function after myocardial infarction in mice.