Author

Anand Prakash Singh

University of MichiganORCID 0000-0002-9409-1366Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cell Biology· 1 Immunology· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:mouse· 3 Assay:bulk RNA-seq· 2 Research Focus:host-pathogen & immune response· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:metabolism & bioenergetics· 1 Approach:statistical model· 1

Frequent Co-Authors

Afnan AlzamrooniiD· 2 shared Ahmed Abdel‐LatifiD· 2 shared Parisa ShabaniiD· 2 shared Rachel Lopez‐Schenk· 2 shared Rajesh Kumar ChaudharyiD· 2 shared Tahra Kaur Luther· 2 shared Anis IsmailiD· 1 shared Bertram PittiD· 1 shared

Activity by Year

2021-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 34 mutual co-author links

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2 shared papersImmunology

Afnan AlzamrooniORCID

Mutual co-authors in cluster

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3 papers

Recent·Most cited

Soluble Urokinase Plasminogen Activator Receptor Primes Macrophages and Worsens Heart Failure with Preserved Ejection Fraction

Anand Prakash Singh, Parisa Shabani, Anis Ismail, Rajesh Kumar Chaudhary, Afnan Alzamrooni, Tahra Kaur Luther, Matthew Nho, Rachel Lopez‐Schenk, Chetna Soni, Sascha N. Goonewardena, Salim S. Hayek, Ahmed Abdel‐Latif

This paper shows that elevated suPAR worsens HFpEF by priming macrophages and amplifying inflammatory responses, identifying a therapeutic target for anti-suPAR antibodies.

bioRxiv · Jun 9, 2026 · PreprintImmunology

Targeting Metabolic Dysfunction and Inflammation with Sotagliflozin Reverses Diastolic Dysfunction in Experimental HFpEF

Parisa Shabani, Tahra Kaur Luther, Rajesh Kumar Chaudhary, Anand Prakash Singh, Afnan Alzamrooni, Olga G. Grushko, Nathan Levine, Rachel Lopez‐Schenk, Sascha N Goonwardena, Bertram Pitt, Ahmed Abdel‐Latif

This study shows that sotagliflozin improves diastolic dysfunction in HFpEF by enhancing lipid metabolism and reducing inflammation.

bioRxiv · Nov 27, 2025 · PreprintCell Biology

Cardiac fibroblast GSK-3α mediates adverse myocardial fibrosis via IL-11 and ERK pathway

Prachi Umbarkar, Sultan Tousif, Anand Prakash Singh, Joshua Charles Anderson, Qinkun Zhang, Hind Lal

This study identifies GSK-3α in cardiac fibroblasts as a mediator of myocardial fibrosis through the IL-11 and ERK pathway, showing its role in fibroblast activation and cardiac function improvement upon deletion.

bioRxiv · Feb 2, 2021 · PreprintMolecular Biology