Tanel Punga

A novel adenovirus 19K/IX protein enhances infection by attenuating proteasomal degradation of tyrosine-ubiquitinated capsid protein IX

This study identifies the 19K/IX protein as a regulator of HAdV-C5 infection by stabilizing the capsid protein IX through attenuation of proteasomal degradation.

Δ133p53α and Δ160p53α isoforms of the tumor suppressor protein p53 exert dominant-negative effect primarily by co-aggregation

This study identifies that Δ133p53α and Δ160p53α isoforms exert a dominant-negative effect on p53 by co-aggregating with full-length p53, disrupting its function.

Anti-gene oligonucleotides targeting Friedreichs ataxia expanded GAA:TTC repeats increase Frataxin expression

This study shows that anti-gene oligonucleotides targeting GAA*TTC repeats in Friedreichs ataxia increase FXN expression in patient cells.

ZC3H11A interacts with PABPN1 and alters polyadenylation of viral transcripts

This study identifies ZC3H11A as a regulator of polyadenylation of viral transcripts through its interaction with PABPN1 and mRNA.