Author
Chinese Academy of Medical Sciences & Peking Union Medical CollegeORCID 0000-0002-1279-5432Unclaimed ORCID profile · follow to get notified of new preprints
4 papers
Recent·Most cited
Jia Duan, Peiyu Xu, Xiaodong Luan…·H. Eric Xu
The paper reports the structures of TSHR activated by TSH and an autoantibody, revealing a universal activation mechanism and the role of cholesterol in TSHR localization.
Jia Duan, Peiyu Xu, Xi Cheng…·H. Eric Xu
The paper reports cryo-EM structures of LHCGR in different activation states, revealing a push and pull mechanism of receptor activation and the role of an allosteric agonist.
Wanchao Yin, Xiaodong Luan, Zhihai Li…·H. Eric Xu
The paper discovers suramin as a potent inhibitor of SARS-CoV-2 RNA polymerase and provides its structural mechanism for repurposing in treating COVID-19.
Wanchao Yin, Chunyou Mao, Xiaodong Luan…·H. Eric Xu
This study reports the structure of SARS-CoV-2 RdRp with and without Remdesivir, showing how the drug inhibits viral RNA replication by terminating chain elongation.