William C. Wetsel

Structure based discovery of antipsychotic-like TAAR1 agonists

The paper identifies TAAR1 agonists with antipsychotic-like effects through computational screening and experimental validation, showing improved potency and reduced side effects in a schizophrenia model.

A suite of engineered mice for interrogating psychedelic drug actions

This paper introduces engineered mouse models to study the effects of psychedelic drugs by examining HTR2A receptor expression and function.

Hidden Bias: GPCR Polymorphisms and the Genomic Landscape of β- Arrestin Signaling

The paper identifies SNPs in GPCRs that alter β-arrestin signaling bias and shows their potential impact on phenotypic variation.

A two-dose regimen of Qβ virus-like particle-based vaccines elicit protective antibodies against heroin and fentanyl

This study shows that two doses of Qβ virus-like particle-based vaccines generate protective antibodies against heroin and fentanyl in animal models.

Combination of Haloperidol with UNC9994, β-arrestin-biased analog of Aripiprazole, ameliorates schizophrenia-related phenotypes induced by NMDAR deficit in mice.

This study shows that combining haloperidol with UNC9994 reduces schizophrenia-like symptoms in NMDAR-deficient mice.

Establishment of Multi-stage Intravenous Self-administration in Mice

This paper establishes a multi-stage IVSA paradigm in mice for studying addiction, showing that behavioral traits predict vulnerability to drug seeking and relapse.

Conserved YKL-40 changes in mice and humans after postoperative delirium.

This study identifies conserved YKL-40 changes in mice and humans after postoperative delirium, linking systemic and CNS inflammation to neuroimmune interactions.

Proximity Analysis of Native Proteomes Reveals Interactomes Predictive of Phenotypic Modifiers of Autism and Related Neurodevelopmental Conditions

The paper develops a proximity proteomics method in mice to identify protein interactions relevant to autism, revealing new genetic risk factors and functional interactions.

Nervous system reduction in branched-chain amino acid metabolism disrupts hippocampal neurogenesis and memory

This study shows that disrupting BCAA metabolism in the nervous system impairs hippocampal neurogenesis and working memory in mice.

Annexin-A1 tripeptide attenuates surgery-induced neuroinflammation and memory deficits through regulation of the NLRP3 inflammasome

This study investigates the role of the NLRP3 inflammasome in postoperative neuroinflammation and evaluates the neuroprotective effects of the ANXA1-derived peptide ANXA1sp in a mouse model of surgery-induced cognitive deficits.

Effects of LSD are differentially modulated in arrestin knockout mice

This study investigates how LSD affects behavior in mice lacking beta-arrestin 1 or 2, revealing distinct roles for these proteins in mediating LSD's effects.

The broad spectrum mixed-lineage kinase 3 inhibitor URMC-099 prevents acute microgliosis and cognitive decline in a mouse model of perioperative neurocognitive disorders

This study shows that URMC-099 prevents surgery-induced microglial activation and cognitive decline in a mouse model of PND without affecting bone healing.

The cortico-striatal circuit regulates sensorimotor gating via Disc1/Huntingtin-mediated Bdnf transport

This study shows that the cortico-striatal circuit regulates sensorimotor gating through Disc1/Huntingtin-mediated Bdnf transport, with lithium restoring deficits in Disc1-LI mice.

A giant ankyrin-B mechanism for neuro-diversity/divergence through stochastic ectopic axon projections

This paper identifies a cellular mechanism involving giant ankyrin-B that leads to stochastic axon projections and contributes to neurodiversity and ASD.