Author

Madoka Kawaguchi

Tohoku University

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Biochemistry· 1 Cancer Biology· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:experimental assay· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Organism:human· 1 Organism:mouse· 1 Assay:proteomics· 1

Frequent Co-Authors

Hozumi MotohashiiD· 2 shared Ayumi MitsuneiD· 1 shared Ayumi SuzukiiD· 1 shared Haruna TakedaiD· 1 shared Hirohito SanoiD· 1 shared Hiroki SekineiD· 1 shared Hisatoshi SugiuraiD· 1 shared Keito OkazakiiD· 1 shared

Activity by Year

2024-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

2 shared papersCancer Biology

Hozumi MotohashiORCID

Mutual co-authors in cluster

Author profile →

2 papers

Recent·Most cited

Regnase-1 Promotes Tumor-Initiating Activity in Non-Small Cell Lung Cancer

Keito Okazaki, Madoka Kawaguchi, Shohei Murakami, Haruna Takeda, Hiroki Sekine, Osamu Takeuchi, Hozumi Motohashi

This study shows Regnase-1 promotes tumor-initiating activity in NSCLC by suppressing the SOX2 pathway, and its inhibition reduces tumor growth and enhances anti-cancer immunity.

bioRxiv · Jul 8, 2025 · PreprintCancer Biology

Glutathione supersulphide regulates T-cell receptor signalling

Yusaku Sasaki, Tadahisa Numakura, Mitsuhiro Yamada, Hisatoshi Sugiura, Tetsuro Matsunaga, Tomoaki Ida, Masanobu Morita, Ayumi Suzuki, Shuichiro Matsumoto, Madoka Kawaguchi, Takeshi Kawabe, Shunichi Tayama, Yuko Okuyama, Tsuyoshi Takata, Kenji Inaba, , Hozumi Motohashi

This study shows that glutathione supersulphide regulates T-cell receptor signalling by interacting with the CD3ε chain, affecting TCR activation and inflammation.

bioRxiv · Apr 30, 2024 · PreprintBiochemistry