Author

Haruna Takeda

Harvard UniversityORCID 0000-0003-1213-9619Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Organism:human· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Approach:deep learning· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Organism:mouse· 1 Assay:proteomics· 1

Frequent Co-Authors

Bingsen ZhangiD· 1 shared Edward T. ChouchaniiD· 1 shared Evanna L. MillsiD· 1 shared Guangyan Du· 1 shared Haopeng XiaoiD· 1 shared Hiroki SekineiD· 1 shared Hozumi MotohashiiD· 1 shared Hyuk‐Soo SeoiD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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1 shared paperBiochemistry

Bingsen ZhangORCID

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2 papers

Recent·Most cited

BiochemistryNature Chemical BiologyPeer-reviewedMar 12, 2026

A druggable redox switch on SHP1 controls macrophage inflammation

Mei Ying Ng, Meredith Nicole Nix, Guangyan Du…·Edward T. Chouchani

This paper identifies a druggable redox switch on SHP1 that controls macrophage inflammation by developing a covalent agonist targeting a specific cysteine residue.

3 citationstop 4%

humanmouse

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Cancer BiologybioRxivPreprintJul 8, 2025

Regnase-1 Promotes Tumor-Initiating Activity in Non-Small Cell Lung Cancer

Keito Okazaki, Madoka Kawaguchi, Shohei Murakami…·Hozumi Motohashi

This study shows Regnase-1 promotes tumor-initiating activity in NSCLC by suppressing the SOX2 pathway, and its inhibition reduces tumor growth and enhances anti-cancer immunity.

DOI 10.1101/2025.07.08.663650

humanbulk RNA-seq

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