Jennifer E Snyder-Cappione

This paper generates functional CD4+ T cells from human iPSC by modulating Notch signaling, showing cytokine diversity and transcriptional similarity to blood CD4+ T cells.

This paper introduces a 50-marker mass cytometry panel to comprehensively profile functional diversity in human immune cells, detecting cytokines and chemokines beyond traditional panels.

This study compares CyTOF with fluorescent cytometry for detecting intracellular markers, finding CyTOF provides superior resolution for phosphoproteins, transcription factors, and cytokines, enabling better immune cell clustering and discovery of unique populations.

The paper develops a mouse model that exhibits severe SARS-CoV-2 infection and post-acute systemic diseases, revealing molecular mechanisms of PASC.

The paper introduces opt-SNE, an automated t-SNE parameter selection tool that improves visualization and analysis of large single-cell datasets by optimizing early exaggeration and gradient descent settings.