Shu Liu

This study evaluates transcriptomic and morphological profiling methods for hazard assessment using reference chemicals in renal cells, finding HTTr provides higher mechanistic resolution than CPP.

The paper evaluates Cell Painting (CP) and Cell Painting PLUS (CPP) for predicting compound mechanisms of action, finding CPP better resolves off-target effects and improves MoA prediction for lysosome-related compounds.

This study uses Cell Painting PLUS to identify nephrotoxicity-related morphological signatures in human RPTEC/TERT1 cells by analyzing over 300 compounds.

This study shows endogenous retroviruses enhance prion-like spreading of protein aggregates between cells, suggesting antiviral drugs could inhibit disease progression.

The paper shows viral ligand-receptor interactions enhance the spread of protein misfolding via extracellular vesicles and direct cell contact.