Author

Tiziana Petrozziello

Massachusetts General HospitalORCID 0000-0002-5487-1667Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Neuroscience· 3

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:differential expression· 2 Organism:human· 2 Assay:proteomics· 2 Research Focus:cell type annotation· 1 Research Focus:drug response / drug discovery· 1 Organism:mouse· 1 Research Focus:protein structure prediction· 1

Frequent Co-Authors

Ellen SappiD· 3 shared Ghazaleh Sadri‐VakiliiD· 3 shared Marian DiFigliaiD· 3 shared Adel BoudiiD· 2 shared Kimberly B. Kegel-GleasoniD· 2 shared Abigail A. Obeng-MarnuiD· 1 shared Alexandra N. MillsiD· 1 shared Ana Claudia Silva AmaraliD· 1 shared

Activity by Year

2021-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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3 shared papersNeuroscience

Ellen SappORCID

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3 papers

Recent·Most cited

WWOX contributes to DNA damage, but not somatic instability in Huntington s disease

Tiziana Petrozziello, Zachariah L. McLean, Adel Boudi, Sommer S. Huntress, Eric J. Granucci, Grace A Field, Ranee Zara B. Monsanto, Ayleen L. Castillo Torres, Jennie C. L. Roy, Maheswaran Kesavan, Muzhou Wu, Neil Doherty, Ellen Sapp, Mahmoud A. Pouladi, Kimberly B. Kegel-Gleason, , Ghazaleh Sadri‐Vakili

This study investigates the role of WWOX in DNA damage and somatic instability in Huntington's disease, finding that WWOX promotes DNA damage but not CAG repeat instability.

bioRxiv · Jun 26, 2026 · PreprintNeuroscience

Early reduction and impaired targeting of myelin-associated glycoprotein to myelin membranes in Huntington disease

Adel Boudi, Ellen Sapp, Yvonnie Y Li, Kai Shing, Kimberly B. Kegel-Gleason, Tiziana Petrozziello, Ghazaleh Sadri‐Vakili, Neil Aronin M. D, Marian DiFiglia, Xueyi Li

This study identifies early reduction and impaired trafficking of myelin-associated glycoprotein in Huntington disease mouse models, contributing to white matter degradation.

bioRxiv · Oct 15, 2025 · PreprintNeuroscience

Targeting tau mitigates mitochondrial fragmentation and oxidative stress in amyotrophic lateral sclerosis

Tiziana Petrozziello, Evan A. Bordt, Alexandra N. Mills, Spencer E. Kim, Ellen Sapp, Benjamin A. Devlin, Abigail A. Obeng-Marnu, Sali M.K. Farhan, Ana Claudia Silva Amaral, Simon Dujardin, Patrick M. Dooley, Christopher M. Henstridge, Derek H. Oakley, Andreas Neueder, Bradley T. Hyman, , Ghazaleh Sadri‐Vakili

This study shows that reducing tau with a degrader prevents mitochondrial fragmentation and oxidative stress in ALS models.

Molecular Neurobiology · Nov 10, 2021Peer-reviewedNeuroscience