Molecular BiologybioRxivPreprint
Targeting ADORA-PDE10 cAMP Microdomain: A Novel Therapeutic Approach for Pulmonary Hypertension
Chanil Valasarajan, Golnaz Hesami, Giovanni Maroli…·Soni Savai Pullamsetti
This study shows that targeting ADORA1 and PDE10A together improves PAH symptoms in animal models by increasing cAMP levels and reducing vascular remodeling.
DOI 10.1101/2024.10.27.616460