Extracellular protein catabolism drives regulated nitrogen handling and ammonia buffering in acute myeloid leukemia
Nina Kurrle, Philipp Makowka, Vera Schlipfenbacher, Johanna Kreitz, Islam Alshamleh, Marcel Seibert, Sifora Kaleab, Celestine Aguilar Montero, Silvia Marín, Dominik Christian Fuhrmann, Florian Gatzke, Claudia Fernandes, Nidhi Preman, Bjoern Haeupl, Sebastian Wolf, , Hubert L. Serve
This study shows AML cells use extracellular protein catabolism to supply amino acids and manage nitrogen, with GS/GLUL playing a key role in ammonia buffering and disease progression.
bioRxiv · Aug 28, 2026 · PreprintCancer Biology