Developmental BiologybioRxivPreprint
Biophysical dissection of SOX18/NR2F2 transcriptional antagonism reveals mechanisms of venous differentiation and drug action in vascular malformation
Matthew S. Graus, Sawan Kumar Jha, Jieqiong Lou…·Mathias François
This study identifies a biophysical mechanism of SOX18/NR2F2 transcriptional antagonism that governs venous differentiation and shows that inhibiting SOX18 can improve vascular malformation symptoms.
DOI 10.1101/2025.04.25.650344