Mathias François

Piezo1 couples fluid shear stress to adaptive genome dynamics by integrating cytoplasmic-nuclear mechanotransduction

The paper shows that Piezo1 mediates fluid shear stress-induced nuclear remodeling and chromatin reorganization in endothelial cells by linking cytoplasmic and nuclear mechanotransduction.

Oncogenic virus hijacks SOX18 pioneer function to enhance viral persistence

This study shows KSHV uses SOX18 to maintain viral episomes in LECs by enhancing chromatin accessibility.

NKX2-5 congenital heart disease mutations show diverse loss and gain of epigenomic, biochemical and chromatin search functions underpinning pathogenicity

The paper investigates NKX2-5 mutations in congenital heart disease by analyzing their epigenomic, biochemical, and chromatin search functions in cardiomyocytes, revealing diverse loss and gain-of-function defects.

Biophysical dissection of SOX18/NR2F2 transcriptional antagonism reveals mechanisms of venous differentiation and drug action in vascular malformation

This study identifies a biophysical mechanism of SOX18/NR2F2 transcriptional antagonism that governs venous differentiation and shows that inhibiting SOX18 can improve vascular malformation symptoms.

Hippo signalling regulates the nuclear behaviour and DNA dwell times of YAP and TEAD to control transcription

This study uses live microscopy to show that Hippo signalling regulates transcription by controlling the DNA dwell times of YAP and TEAD proteins.

An endothelial SOX18-mevalonate pathway axis enables repurposing of statins for infantile hemangioma

The paper identifies a SOX18-mevalonate pathway axis in infantile hemangioma and suggests repurposing statins as a treatment.

RNA-mediated SOX2 temporal dynamics govern dual chromatin engagement modes at Nanog

The paper uses single-molecule imaging to show RNA fluctuations modulate SOX2 dynamics at the Nanog locus, revealing RNA-dependent feedback in transcriptional regulation.

R(+) Propranolol decreases lipid accumulation in hemangioma-derived stem cells

This study shows R(+) propranolol reduces lipid accumulation in hemangioma-derived stem cells in vitro and in a mouse model, without affecting adipogenic transcription factors.

The blood vasculature instructs lymphatics patterning in a SOX7-dependent manner

This study identifies SOX7 as a transcription factor in blood vascular endothelial cells that represses Vegfc expression, influencing lymphatic vessel patterning in mice.

Pkd1 and Wnt5a genetically interact to control lymphatic vascular morphogenesis in mice

This study identifies a genetic interaction between Pkd1 and Wnt5a in controlling lymphatic vascular morphogenesis in mice, showing mutual suppression of lymphatic defects.