ImmunologyCell ReportsPeer-reviewed
Distinct causes of three phenotypic hallmarks of hematopoietic aging
Dennis J. Chia, Apeksha Singh, Yusheng Lin…·Alexander Hoffmann
This study identifies distinct causes for three hematopoietic aging phenotypes using mouse models and single-cell analysis, showing HSC accumulation is NFκB-independent, functional impairment is HSC-autonomous NFκB-driven, and myeloid bias is driven by the NFκB-altered bone marrow environment.