Chiara Falciani

Branching Suppresses Self-Aggregation while Preserving Membrane Association in SET-M33: An Atomistic Molecular Dynamics Study

This study uses molecular dynamics simulations to show that branching in SET-M33 reduces self-aggregation while maintaining membrane association compared to its linear counterpart Q33.

A Conditional Variational Autoencoder with QSAR-Guided Surrogate-Weighted Fine-Tuning and Cross-Entropy Optimization for Targeted Antimicrobial Peptide Generation

This paper introduces a conditional variational autoencoder for antimicrobial peptide generation, combining QSAR data and cross-entropy optimization to overcome limitations in generative models.

In vitro efficacy of synthetic antimicrobial peptide SET-M33 against poultry isolates with diverse antimicrobial resistance phenotypes

This study evaluates the efficacy of the synthetic antimicrobial peptide SET-M33 against poultry pathogens, showing broad inhibition of bacterial growth and host compatibility in intestinal organoids.

Establishment and application of a vesicle extraction method for clinical strains of Pseudomonas aeruginosa

The paper evaluates a rapid vesicle extraction method for clinical Pseudomonas aeruginosa strains, showing its effectiveness but also highlighting challenges with contaminant removal.

SET-M33 peptide as a selective in vitro antimicrobial agent against the porcine respiratory pathogen Glaesserella parasuis

This study evaluates the antimicrobial peptide SET-M33 against Glaesserella parasuis and porcine commensals, showing its selectivity and potential for in vitro use.

A compact prism-based microscope for high sensitive measurements in fluid biopsy

This paper introduces a compact prism-based microscope for sensitive detection of biomarkers in fluid samples, achieving a 1 fg/mL limit of detection for bacterial lipopolysaccharides.

Branched Oncolytic Peptides Target HSPGs, Inhibit Metastasis, and Trigger the Release of Molecular Determinants of Immunogenic Cell Death in Pancreatic Cancer.

This paper introduces two branched oncolytic peptides, BOP7 and BOP9, which target HSPGs, inhibit metastasis, and induce immunogenic cell death in pancreatic cancer cells.