Karl Kochanowski

High-throughput, single-cell-encoded colony imaging reveals infection-linked heterogeneity

HeteroTyper quantifies phenotypic heterogeneity in bacterial colonies across multiple media types, revealing tissue-specific differences and growth dynamics during infection.

Genome-scale metabolic model atlas of the zoonotic pathogen Streptococcus suis

This study creates a genome-scale metabolic model atlas for Streptococcus suis, revealing lineage-specific metabolic differences and identifying potential antimicrobial targets.

In vitro efficacy of synthetic antimicrobial peptide SET-M33 against poultry isolates with diverse antimicrobial resistance phenotypes

This study evaluates the efficacy of the synthetic antimicrobial peptide SET-M33 against poultry pathogens, showing broad inhibition of bacterial growth and host compatibility in intestinal organoids.

Airway organoids reveal patterns of Influenza A tropism and adaptation in wildlife species

The paper uses airway organoids from wildlife and livestock species to assess susceptibility to influenza viruses, revealing species-specific infection patterns and adaptation mechanisms.

SET-M33 peptide as a selective in vitro antimicrobial agent against the porcine respiratory pathogen Glaesserella parasuis

This study evaluates the antimicrobial peptide SET-M33 against Glaesserella parasuis and porcine commensals, showing its selectivity and potential for in vitro use.

In vitro metabolic interaction network of a rationally designed nasal microbiota community

The paper develops a microbial consortium to study nasal microbiota metabolic interactions and finds that most interactions are negative, driven by sugar co-depletion and leading to competitive hierarchies.

Porcine Nasal Organoids as a model to study the interactions between the swine nasal microbiota and the host

This paper develops porcine nasal organoids to study host-microbe interactions in respiratory infections and shows that Rothia nasimurium inhibits inflammation from other bacteria.

Loss of Tet2 affects proliferation and drug sensitivity through altered dynamics of cell-state transitions

This study shows that Tet2 loss-of-function in AML cells alters cell-state transitions, improving survival during drug treatment and contributing to relapse.

Stress-Induced Transient Cell Cycle Arrest Coordinates Metabolic Resource Allocation to Balance Adaptive Tradeoffs

The paper shows that removing stress-induced cell cycle arrest in yeast accelerates osmotic shock adaptation but increases vulnerability to subsequent stress.