Respiratory-restricted SARS-CoV-2 infection in mice, without brain virus, drives white matter microglial reactivity, impaired neurogenesis, oligodendrocyte depletion and myelin loss lasting at least 7 weeks.

bioRxiv · Jan 7, 2022 · PreprintNeuroscience✦ In-depth digest

Multiscale PHATE Exploration of SARS-CoV-2 Data Reveals Multimodal Signatures of Disease

Manik Razdan Kuchroo, Jessie Huang, Patrick Wong, Jean‐Christophe Grenier, Dennis Legen Shung, Alexander Tong, Carolina Gonçalves de Oliveira Lucas, Jon Klein, Daniel B. Burkhardt, Scott Gigante, Abhinav Godavarthi, Benjamin Israelow, Tianyang Mao, Ji Eun Oh, Júlio Dos Santos Silva, , Smita Krishnaswamy

The paper introduces Multiscale PHATE, a method for exploring high-dimensional biomedical data, and applies it to identify immune cell signatures associated with severe COVID-19 outcomes.

bioRxiv · Nov 15, 2020 · PreprintBioinformatics

A Molecular Mechanism for Probabilistic Bet-hedging and its Role in Viral Latency

Sonali Chaturvedi, Jon Klein, Noam Vardi, Cynthia Bolovan‐Fritts, Marie Wolf, Kelvin H. Du, Luwanika Mlera, Meredith Calvert, Nathaniel J. Moorman, Felicia D. Goodrum, Bo Huang, Leor S. Weinberger

The paper identifies stochastic variability in viral tegument protein abundance as a mechanism for probabilistic bet hedging between viral replication and latency in herpesvirus.

Proceedings of the National Academy of Sciences · Jul 6, 2020Peer-reviewedMolecular Biology