Beta-arrestin 1 mediated Src activation via Src SH3 domain revealed by cryo-electron microscopy
Natalia Pakharukova, Brittany N. Thomas, Harsh Bansia, Linus Li, Dana K. Bassford, Rinat R. Abzalimov, Jihee Kim, Alem W. Kahsai, Biswaranjan Pani, Kunhong Xiao, Roni Ochakovski, Shibo Liu, Xingdong Zhang, Seungkirl Ahn, Amédée des Georges, Robert J. Lefkowitz
The paper reveals how beta-arrestin 1 activates Src kinase via two distinct SH3 domain interactions, using cryo-EM to show structural mechanisms of beta-arrestin-mediated signaling.
Nature Communications · Feb 20, 2026Peer-reviewedBiochemistry