Author
Pfizer (United States)ORCID 0000-0002-1070-3880Unclaimed ORCID profile · follow to get notified of new preprints
3 papers
Recent·Most cited
Kevin W. Huynh, Rachel Plumb, David R. Healy…·Masaya Yamaguchi
The paper determines the structure of the STAT2-USP18-ISG15 ternary complex using cryo-EM, revealing how USP18's scaffolding function suppresses IFN-I signaling by disrupting its enzymatic activity.
Natalie C. Silmon de Monerri, Ye Che, Joshua A. Lees…·Robert G. K. Donald
The paper designs a conformationally stabilized FimH antigen for a UTI vaccine, showing improved immunogenicity and structural similarity to native FimH.
David Jon Wasilko, Brian S. Gerstenberger, Kathleen A. Farley…·Huixian Wu
This paper presents two inactive CCR6 structures bound to allosteric antagonists, revealing structural insights into CCR6 inhibition and its implications for drug discovery.