Menno P. Creyghton

Time-resolved single-cell state tracing exposes bidirectional state dynamics during differentiation

The paper uses single-cell state tracing to show bidirectional differentiation dynamics and rare transcriptome conversions across lineage boundaries in both in vivo and in vitro settings.

Retrospective analysis of enhancer activity and transcriptome history

The paper uses a novel method to track enhancer activity and transcriptome changes during intestinal stem cell differentiation, revealing insights into lineage decisions and chromatin dynamics.

A genome-wide CRISPR/Cas phenotypic screen formodulators of DUX4 cytotoxicity reveals screen complications

The paper performs a genome-wide CRISPR/Cas9 screen to identify modulators of DUX4 cytotoxicity in FSHD but finds no key effectors other than DUX4 itself.