Author

Oliver Florey

Babraham InstituteORCID 0000-0002-1075-7424Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cell Biology· 3 Immunology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell signaling & trafficking· 4 Approach:experimental assay· 4 Assay:proteomics· 3 Research Focus:cell type annotation· 2 Organism:mouse· 2 Approach:biophysical modeling· 1 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

Joanne DurganiD· 2 shared Abdelmnim RadouaiD· 1 shared Ameetha Ratier· 1 shared Camila Figueiredo PinzaniD· 1 shared Carmen GarridoiD· 1 shared Carolina BifanoiD· 1 shared Caroline Patini RezendeiD· 1 shared Caroline TruntzeriD· 1 shared

Activity by Year

2024-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 18 mutual co-author links

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2 shared papersCell Biology

Joanne DurganORCID

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4 papers

Recent·Most cited

CASM regulates p62/KEAP1/NRF2 antioxidant responses to lysosome damage

Yasmeen Safayd, Karen E. Anderson, Sophie Blagg, Joanne Durgan, Ruchi Sharma, Oliver Florey

This study identifies CASM as a regulator of antioxidant responses to lysosome damage by activating the p62/KEAP1/NRF2 pathway.

bioRxiv · Jul 8, 2026 · PreprintCell Biology

CASM potentiates STING-driven NFκB signaling in immune cells

Isis Benoit-Lizon, Cassandre Pignol, Kirsty M. Hooper, Caroline Truntzer, Abdelmnim Radoua, Ludivine Dal Zuffo, Julie Lucas, Quentin Frenger, Emy Ponsardin, Clarisse Cornebise, Isabelle Cantaloube, Ameetha Ratier, Romain Aucagne, François Hermetet, Sayyed Hamed Shahoei, , Lionel Apétoh

The paper investigates the role of CASM in STING signaling, finding that CASM enhances NFκB-driven TNF production while autophagy exerts negative feedback on STING pathways.

bioRxiv · Jan 24, 2026 · PreprintCell Biology

RAB5c controls the assembly of non-canonical autophagy machinery to promote phagosome maturation and microbicidal function of macrophages

Edismauro Garcia Freitas Filho, Isabella Zaidan, Marlon Fortes-Rocha, Daniel Leonardo Alzamora-Terrel, Carolina Bifano, Patrícia Alves de Castro, Renan Eugênio Araujo Piraine, Camila Figueiredo Pinzan, Caroline Patini Rezende, Emilio Boada-Romero, Fausto Bruno dos Reis Almeida, Gustavo Henrique Goldman, Oliver Florey, Larissa D. Cunha

This study identifies RAB5c's role in regulating non-canonical autophagy machinery to enhance phagosome maturation and microbial killing by macrophages.

bioRxiv · Mar 25, 2025 · PreprintImmunology

A distinctive PI(4,5)P2 compartment forms during entosis and related engulfment processes

Joanne Durgan, Katherine Sloan, Marie‐Charlotte Domart, Lucy Collinson, Oliver Florey

The paper identifies a unique PI(4,5)P2-positive compartment formed during entosis and related engulfment processes, distinct from phagosomes and macropinosomes.

bioRxiv · Oct 22, 2024 · PreprintCell Biology