Cell BiologyMolecular Biology of the CellPeer-reviewed
Inducible FAK Deletion but not FAK Inhibition in Endothelial Cells Activates p53 to Suppress Tumor Growth in PYK2-null Mice
Xiao Lei Chen, Marjaana Ojalill, Christine Jean…·David D. Schlaepfer
The paper shows that deleting FAK in endothelial cells of PYK2-null mice activates p53, suppresses tumor growth, and limits metastasis, while FAK inhibition has different effects.
5 citations