Author

David D. Schlaepfer

University of California San DiegoORCID 0000-0003-4814-9210Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cancer Biology· 1 Cell Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:cancer & tumor microenvironment· 2 Approach:experimental assay· 2 Organism:mouse· 2 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1

Frequent Co-Authors

Antonia D. BoyeriD· 2 shared Duygu OzmadenciiD· 2 shared Dwayne G. StupackiD· 2 shared Marjaana OjalilliD· 2 shared Xiao Lei CheniD· 2 shared Alfredo MolinoloiD· 1 shared Christine JeaniD· 1 shared Christine LawsoniD· 1 shared

Activity by Year

2025-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 41 mutual co-author links

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2 shared papersCancer Biology

Antonia D. BoyerORCID

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2 papers

Recent·Most cited

Cancer BiologybioRxivPreprintSep 12, 2025

Ovarian Tumor FAK Inhibition Releases Omega-3 Fatty Acids Stimulating GATA6 Peritoneal Macrophage CXCL13 Production Enhancing Immunotherapy

Xiao Lei Chen, Kevin M. Tharp, Marjaana Ojalill…·David D. Schlaepfer

This study shows FAK inhibition in ovarian tumors increases macrophage CXCL13 production via omega-3 fatty acids, enhancing B cell infiltration and immunotherapy response.

DOI 10.1101/2025.09.12.675975

mousehuman

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Cell BiologyMolecular Biology of the CellPeer-reviewedApr 9, 2025

Inducible FAK Deletion but not FAK Inhibition in Endothelial Cells Activates p53 to Suppress Tumor Growth in PYK2-null Mice

Xiao Lei Chen, Marjaana Ojalill, Christine Jean…·David D. Schlaepfer

The paper shows that deleting FAK in endothelial cells of PYK2-null mice activates p53, suppresses tumor growth, and limits metastasis, while FAK inhibition has different effects.

5 citations

mouseexperimental assay

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