This study shows that palmitoylation of FRS2α is essential for FGF1-induced signaling and cellular responses, including MAPK activation and neuronal differentiation.

Proceedings of the National Academy of Sciences · Apr 29, 2026Peer-reviewedBiochemistry

Inducible FAK Deletion but not FAK Inhibition in Endothelial Cells Activates p53 to Suppress Tumor Growth in PYK2-null Mice

Xiao Lei Chen, Marjaana Ojalill, Christine Jean, Isabelle Tancioni, Shulin Jiang, Antonia D. Boyer, Duygu Ozmadenci, Sean A. Uryu, David Tarin, Joseph Schlessinger, Dwayne G. Stupack, David D. Schlaepfer

The paper shows that deleting FAK in endothelial cells of PYK2-null mice activates p53, suppresses tumor growth, and limits metastasis, while FAK inhibition has different effects.

Molecular Biology of the Cell · Apr 9, 2025Peer-reviewedCell Biology

Robust de novo design of protein binding proteins from target structural information alone

Longxing Cao, Brian Coventry, Inna Goreshnik, Buwei Huang, Joon Sung Park, Kevin M. Jude, Iva Marković, Rameshwar U. Kadam, Koen H. G. Verschueren, Kenneth Verstraete, Scott Thomas Russell Walsh, Nathaniel R. Bennett, Ashish Phal, Aerin Yang, Lisa Kozodoy, , David A. Baker

This paper designs small, stable proteins that bind to diverse target proteins using only structural information, achieving nanomolar to picomolar affinities.

bioRxiv · Sep 4, 2021 · PreprintSynthetic Biology