Inducible FAK Deletion but not FAK Inhibition in Endothelial Cells Activates p53 to Suppress Tumor Growth in PYK2-null Mice
Xiao Lei Chen, Marjaana Ojalill, Christine Jean, Isabelle Tancioni, Shulin Jiang, Antonia D. Boyer, Duygu Ozmadenci, Sean A. Uryu, David Tarin, Joseph Schlessinger, Dwayne G. Stupack, David D. Schlaepfer
The paper shows that deleting FAK in endothelial cells of PYK2-null mice activates p53, suppresses tumor growth, and limits metastasis, while FAK inhibition has different effects.
Molecular Biology of the Cell · Apr 9, 2025Peer-reviewedCell Biology