Mechanical control of the splicing factor PTBP1 regulates extracellular matrix stiffness-induced cell proliferation and mechanomemory
Pei-Li Tseng, Weiwei Sun, Ahmed Salem, Mubarak Alaklobie, Sarah C. Macfarlane, Annica K. B. Gad, Mark O. Collins, Kai S. Erdmann
This study identifies PTBP1 as a mechanotransducer that regulates cell proliferation and mechanomemory through mechanosensitive splicing of Numb in response to extracellular matrix stiffness.
iScience · Mar 22, 2025Peer-reviewedCell Biology