Kai S. Erdmann

The paper describes a screening method to identify proteins whose nuclear localization is sensitive to mechanical forces using engineered cell lines and LC-MS/MS.

This study identifies PTBP1 as a mechanotransducer that regulates cell proliferation and mechanomemory through mechanosensitive splicing of Numb in response to extracellular matrix stiffness.

The paper shows that Crumbs2 (CRB2) mediates dorsal collapse in the spinal cord by promoting cell delamination and ventricular layer remodelling.