Sarah C. Macfarlane

This study shows liver metastases reduce checkpoint inhibitor efficacy by increasing splenic granulopoiesis and S100A9hi neutrophils, which suppress T-cell responses, and demonstrates that targeting S100A9 restores efficacy.

This study identifies PTBP1 as a mechanotransducer that regulates cell proliferation and mechanomemory through mechanosensitive splicing of Numb in response to extracellular matrix stiffness.