This study identifies a bidirectional OSMR-CLIC1 crosstalk that drives oncogenic pathways in glioblastoma and suggests targeting this interaction as a therapeutic strategy.

bioRxiv · Mar 5, 2025 · PreprintNeuroscience

Proteomics Reveals Extracellular Matrix Injury in the Glomeruli and Tubulointerstitium of Kidney Allografts with Early Antibody-Mediated Rejection

Sergi Clotet‐Freixas, Caitríona M. McEvoy, Ihor Batruch, Chiara Pastrello, Max Kotlyar, Julie A.D. Van, Madhurangi Arambewela, Alex Boshart, Sofia Farkona, Yun Niu, Yanhong Li, Olusegun Famure, Andrea Božović, Vathany Kulasingam, Peixuen Chen, , Ana Konvalinka

The paper uses proteomics to identify ECM injury in kidney allografts with early AMR, finding decreased ECM proteins and increased LGALS1 and GSTO1 in affected tissues.

Journal of the American Society of Nephrology · Sep 8, 2020Peer-reviewedMolecular Biology

The IMEx Coronavirus interactome: an evolving map of Coronaviridae-Host molecular interactions

Livia Perfetto, Chiara Pastrello, Noemí del‐Toro, Margaret Duesbury, Marta Iannuccelli, Max Kotlyar, Luana Licata, Birgit Meldal, Kalpana Panneerselvam, Simona Panni, Negin Rahimzadeh, Sylvie Ricard‐Blum, Łukasz Salwiński, Anjali Shrivastava, Gianni Cesareni, , Pablo Porras

The paper curates a dataset of physical molecular interactions between SARS-CoV-2, SARS-CoV-1, and other Coronaviridae proteins, providing a resource for studying virus-host interactions.

Database · Jan 1, 2020Peer-reviewedBioinformatics

Capturing variation impact on molecular interactions: the IMEx Consortium mutations data set

J. Khadake, Birgit Meldal, Simona Panni, David Thorneycroft, K. Van Roey, Sara Abbani, Łukasz Salwiński, Matteo A. Pellegrini, Marta Iannuccelli, Luana Licata, G. Cesareni, Bernd Roechert, Alan James Bridge, Mais G. Ammari, Fiona McCarthy, , Pablo Porras

The paper presents a dataset of 28,000 annotations describing how amino acid mutations affect protein interactions, available through the IntAct website.

Nature Communications · Dec 27, 2018Peer-reviewedBioinformatics