Kalum Clayton

This paper introduces GARS, a genetic algorithm with rank selection, for parameter estimation in biological models, showing strong accuracy and superiority over existing methods.

The paper identifies TNF-driven transcriptional programs in Langerhans cells that regulate immunogenic and tolerogenic responses through IRF1 and other transcription factors.

The paper identifies that Langerhans cells (LCs) upregulate a tolerogenic gene module during migration, which is critical for inducing regulatory T cells.

The paper identifies IRF4 as a key transcription factor driving antigen cross-presentation in human Langerhans cells, distinguishing them from conventional dendritic cells.