Marta Ewa Polak

This study creates a comprehensive CD4+ Th2 single-cell atlas across diseases and tissues, revealing distinct cytokine functions and potential therapeutic strategies for allergic and inflammatory conditions.

This paper introduces GARS, a genetic algorithm with rank selection, for parameter estimation in biological models, showing strong accuracy and superiority over existing methods.

The paper compares immune responses in influenza and SARS-CoV-2 infected patients and COVID-19 survivors using transcriptomic data, identifying distinct immune signatures and prognostic indicators.

The paper identifies TNF-driven transcriptional programs in Langerhans cells that regulate immunogenic and tolerogenic responses through IRF1 and other transcription factors.

The paper introduces C-DropSeq, a method that improves sensitivity in single-cell transcriptomics by reducing sequencing depth and costs, and demonstrates its application in identifying rare dendritic cell sub-populations.

The paper identifies that Langerhans cells (LCs) upregulate a tolerogenic gene module during migration, which is critical for inducing regulatory T cells.