Jonathan J. West

Droplet microfluidics reports digital and tuneable single-platelet ADP secretion describing primed, active and hyper-active states

The paper introduces DASA, a method to measure single-platelet ADP secretion, revealing distinct states of platelet reactivity and potential clinical applications.

TNF signalling fine-tunes Langerhans cell transcriptional programmes mediating adaptive immunity.

The paper identifies TNF-driven transcriptional programs in Langerhans cells that regulate immunogenic and tolerogenic responses through IRF1 and other transcription factors.

Resolving cellular systems by ultra-sensitive and economical single-cell transcriptome filtering

The paper introduces C-DropSeq, a method that improves sensitivity in single-cell transcriptomics by reducing sequencing depth and costs, and demonstrates its application in identifying rare dendritic cell sub-populations.

An integrated model system to gain mechanistic insights into biofilm formation and antimicrobial resistance development in Pseudomonas aeruginosa MPAO1

The paper validates a model system to identify genes involved in biofilm formation and antibiotic resistance in Pseudomonas aeruginosa MPAO1 using genomics and experimental approaches.

Mapping biology from mouse to man using transfer learning

This paper uses transfer learning to map biology from mouse to human bone marrow using single-cell RNA-sequencing data, showing improved accuracy with retraining and zero-shot learning.

Single cell transcriptomic analysis identifies Langerhans cells immunocompetency is critical for ability to induce tolerogenic T cells.

The paper identifies that Langerhans cells (LCs) upregulate a tolerogenic gene module during migration, which is critical for inducing regulatory T cells.

Efficient propagation of misfolded tau between individual neurons occurs in absence of degeneration

The paper shows misfolded tau spreads between neurons in a prion-like manner without causing immediate cell death.