Author

Sofía Sirvent

University of SouthamptonORCID 0000-0003-0050-8579Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:statistical model· 3 Research Focus:gene regulatory network inference· 2 Organism:human· 2 Assay:scRNA-seq· 2 Research Focus:benchmarking· 1 Research Focus:cell type annotation· 1 Research Focus:clustering· 1 Research Focus:differential expression· 1

Frequent Co-Authors

Andrés F. VallejoiD· 3 shared James DaviesiD· 3 shared Kalum ClaytoniD· 3 shared Marta Ewa PolakiD· 3 shared Ben D. MacArthuriD· 2 shared Gemma Porter· 2 shared Jonathan J. WestiD· 2 shared Michael R. Ardern‐JonesiD· 2 shared

Activity by Year

2019-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 44 mutual co-author links

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3 shared papersSystems Biology

Andrés F. VallejoORCID

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3 papers

Recent·Most cited

Systems BiologybioRxivPreprintFeb 22, 2022

Rank Selection Genetic Algorithm optimises robust parameter estimation for systems biology models

Gemma Douilhet, Mahesan Niranjan, Andrés F. Vallejo…·Marta Ewa Polak

This paper introduces GARS, a genetic algorithm with rank selection, for parameter estimation in biological models, showing strong accuracy and superiority over existing methods.

DOI 10.1101/2022.02.22.481394

optimal transportstatistical model

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Systems BiologybioRxivPreprintFeb 7, 2021

TNF signalling fine-tunes Langerhans cell transcriptional programmes mediating adaptive immunity.

James Davies, Andrés F. Vallejo, Sofía Sirvent…·Marta Ewa Polak

The paper identifies TNF-driven transcriptional programs in Langerhans cells that regulate immunogenic and tolerogenic responses through IRF1 and other transcription factors.

DOI 10.1101/2021.02.07.430111

humanscRNA-seq

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Systems BiologybioRxivPreprintDec 20, 2019

Single cell transcriptomic analysis identifies Langerhans cells immunocompetency is critical for ability to induce tolerogenic T cells.

James Davies, Sofía Sirvent, Andrés F. Vallejo…·Marta Ewa Polak

The paper identifies that Langerhans cells (LCs) upregulate a tolerogenic gene module during migration, which is critical for inducing regulatory T cells.

5 citations

humanscRNA-seq

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