Yuxin Liang

The paper identifies synthetic lethality between POLE exonuclease deficiency and high aneuploidy in cancer cells, suggesting POLE inhibition as a therapeutic strategy for aneuploid tumors.

TumorLens detects genetic and epigenetic alterations in cancer using long reads, revealing key somatic events and methylation patterns across tumor samples.

Epiregulon infers single-cell TF activity using ATAC-seq and RNA-seq to predict drug response and identify drivers of cell state.

OAK enables ultra-high throughput single-cell multiomic profiling with high sensitivity and reduced labor, demonstrating its utility in detecting rare resistant cell populations.

This study introduces scTaILoR-seq, a long-read targeted RNA sequencing method, to enhance single-cell transcriptome analysis and identify isoform variation and SNV associations in ovarian cancer.

This study compares ten commercial scRNA-seq technologies using PBMCs, finding the 10x Genomics kit offers superior performance and the Becton Dickinson kit provides cost-effective performance per cell.