Manuel Javier Muñoz

OmpA controls intracellular survival of Acinetobacter baumannii through TFEB activation and lysosomal remodeling

This study identifies an OmpA-iPLA2-LPC-ORAI1-TFEB signaling axis that enables Acinetobacter baumannii to survive intracellularly by modulating lysosomal function and counteracting host defenses.

RNA Polymerase II Degradation Triggered by DNA Repair Occurs In Trans and Independently of how the Lesion is Recognised

The paper shows that RPB1 degradation by the ubiquitin-proteasome system occurs in trans and is controlled by NER activity, regardless of lesion recognition mechanism.