Weixiang Fang

This study identifies a gene signature of metastatic potential by linking pre-metastatic states to metastatic outcomes in mouse pancreatic cancer and validates its relevance in human tumors.

This paper introduces a consensus variant-to-function score to prioritize disease-causing variants, showing improved performance in heritability enrichment and fine-mapping.

The paper introduces FUNCODE, a framework to quantify functional conservation between human and mouse regulatory elements using in silico sample matching, identifying 3.3 million conserved element pairs and demonstrating its applications in annotation and cross-species data integration.

The paper examines regional gene expression differences in the retina, optic nerve head, and optic nerve of mice with glaucoma and optic nerve crush using bulk RNA-sequencing.

The paper identifies novel pathways that enhance oligodendrocyte maturation and myelination through high-throughput screening of 2500 compounds using engineered human stem cell-derived OPCs.

This paper introduces quantitative fate mapping to reconstruct progenitor field dynamics using lineage barcodes and validates it with simulations and experiments.