Jun Li

This study shows that transcriptomic features, not genomic characteristics, drive the histologic phenotype of lung cancers.

The paper compiles protein response data from cancer cell lines to drug perturbations, showing improved drug sensitivity prediction and building a protein-drug connectivity map with an accessible data portal.

This study examines genomic and TCR repertoire heterogeneity in SCLC, finding that lower TCR heterogeneity and mutational burden correlate with better survival.

This study characterizes mitochondrial genomes in 2,700 cancer patients across 37 types using whole-genome sequencing and RNA-seq, revealing mutational patterns, truncating mutations, and nuclear transfer of mitochondrial DNA.

This study identifies p53's role in suppressing mutagenic DNA repair pathways by regulating replication restart, revealing its importance in genomic stability and cancer therapy resistance.