Lou Vinarcsik

The paper shows that a high fat diet worsens Alzheimer's disease symptoms in mice but does not synergistically reduce cerebral blood flow, suggesting capillary stalling is not the mechanism linking diet and disease severity.

This study identifies neutrophil adhesion in brain capillaries as a cause of reduced cerebral blood flow and impaired memory in an Alzheimer's mouse model, showing that targeting this adhesion improves both CBF and memory.