Calvin J. Kersbergen

The paper shows that in deaf mice lacking connexin 26, cochlear supporting cells retain spontaneous activity, preserving early auditory circuit development despite structural cochlear changes.

This study shows that cochlear spontaneous activity during development is crucial for proper auditory circuit maturation, affecting frequency tuning and neural gain.

The paper shows that purinergic signaling via ATP release from inner supporting cells drives spontaneous activity in the auditory system from birth to hearing onset, promoting coordinated neural firing in frequency-specific circuits.

This study shows that purinergic signaling in cochlear supporting cells regulates hair cell excitability by altering extracellular space volume through K+ dynamics.

This study identifies neutrophil adhesion in brain capillaries as a cause of reduced cerebral blood flow and impaired memory in an Alzheimer's mouse model, showing that targeting this adhesion improves both CBF and memory.