Oliver Bracko

This study shows that reducing neutrophil sialic acid residues improves cerebral blood flow in Alzheimer's models by decreasing capillary stalling.

This study shows that progranulin deficiency causes microvascular and neurovascular unit changes in FTD-GRN, affecting perfusion and signaling pathways.

The paper identifies shared and disease-specific vascular signatures in Alzheimer's, frontotemporal dementia, and Huntington's disease using transcriptomic analysis of brain vessel datasets.

In a mouse model of focal epilepsy, sub-surface laser-produced cuts encircling the seizure focus attenuate propagation without behavioral impairment.

This study shows that inhibiting NOX2 reduces capillary stalling and inflammation in Alzheimer's mice, improving memory and blood flow.

This study shows that inhibiting VEGF signaling in AD mice reduces leucocyte adhesion in brain capillaries, increases blood flow, and improves BBB integrity.

This study shows that voluntary running improves memory and neurogenesis in Alzheimer's mouse models but does not increase cerebral blood flow or reduce amyloid-beta deposits.

The paper shows that a high fat diet worsens Alzheimer's disease symptoms in mice but does not synergistically reduce cerebral blood flow, suggesting capillary stalling is not the mechanism linking diet and disease severity.

A single injection of anti-Ly6G improves short-term memory in younger Alzheimer's mice but not older ones, while still increasing cerebral blood flow in older mice.

This study identifies neutrophil adhesion in brain capillaries as a cause of reduced cerebral blood flow and impaired memory in an Alzheimer's mouse model, showing that targeting this adhesion improves both CBF and memory.