Mohammad Haft‐Javaherian

This study shows that inhibiting NOX2 reduces capillary stalling and inflammation in Alzheimer's mice, improving memory and blood flow.

This study shows that inhibiting VEGF signaling in AD mice reduces leucocyte adhesion in brain capillaries, increases blood flow, and improves BBB integrity.

This study shows that voluntary running improves memory and neurogenesis in Alzheimer's mouse models but does not increase cerebral blood flow or reduce amyloid-beta deposits.

The paper shows that a high fat diet worsens Alzheimer's disease symptoms in mice but does not synergistically reduce cerebral blood flow, suggesting capillary stalling is not the mechanism linking diet and disease severity.

A single injection of anti-Ly6G improves short-term memory in younger Alzheimer's mice but not older ones, while still increasing cerebral blood flow in older mice.

This study identifies neutrophil adhesion in brain capillaries as a cause of reduced cerebral blood flow and impaired memory in an Alzheimer's mouse model, showing that targeting this adhesion improves both CBF and memory.